Removal performance of SARS-CoV-2 in wastewater treatment by membrane bioreactor, anaerobic-anoxic-oxic, and conventional activated sludge processesArticle Published on 2022-12-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, 치료제, [키워드] activated applicability CAS chlorination collected COVID-19 outbreak Detection limit evaluate Final fraction independent influent investigated Japan log Log reduction Log reduction value (LRV) lowest membrane Membrane bioreactor (MBR) Mild Pepper mild mottle virus (PMMoV) potential risk quantified reduction removal RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA significantly lower treated Treatment virus wastewater Wastewater treatment plant (WWTP). [DOI] 10.1016/j.scitotenv.2022.158310 PMC 바로가기
Adsorption of SARS-CoV-2 onto granular activated carbon (GAC) in wastewater: Implications for improvements in passive samplingArticle Published on 2022-11-152022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated acute respiratory syndrome Adsorption Adsorption capability anticipated approaches calculated Characteristics Concentration coronavirus DI water experiment feasible granular Granular activated carbon hybrid improvement interval Laboratory limitations occurred offer Passive Passive samplers potential benefit reached reproducibility RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA sensitivity Surveillance viral pathogen virus wastewater Wastewater surveillance. [DOI] 10.1016/j.scitotenv.2022.157548 PMC 바로가기
New insights into antibody levels against SARS-CoV-2 for healthcare personnel vaccinated with tozinameran (Comirnaty)Article Published on 2022-11-032022-11-15 Journal: PLoS ONE [Category] SARS, 진단, [키워드] activated addition addressed administration Alto Andújar antibody booster dose COVID-19 determine Dilution Elecsy Evolution exhibited Germany Guadalquivir healthcare personnel Healthcare professional humoral IgG in vitro infected patients material Neutralizing antibodies New non-infected pandemic platform Roche SARS-CoV-2 SARS-CoV-2 vaccine second dose serum sample Spike protein subject Thermo Fisher Scientific titer total antibody vaccination Vaccine Volunteer volunteers [DOI] 10.1371/journal.pone.0276968 PMC 바로가기
Extended coagulation profile of children with Long Covid: a prospective studyArticle Published on 2022-11-012022-11-16 Journal: Scientific Reports [Category] SARS, 치료기술, [키워드] activated acute SARS-CoV-2 infection Adults age analyzed Antigen Biomarker case-control study change characterized children Coagulation cofactor Cohort control group controls D-dimer level D-dimers Diagnosis eight endothelial damage endotheliopathy enrolled explained Extended females fibrinogen Follow-up FVIII Infection initial International IQR ISARIC Italy Long majority microbiologically no significant difference normalized pediatric plasma profile profiles proportion Prospective Study Prothrombin time respiratory Sample SARS-COV-2 infection Symptom Symptoms the median the SARS-CoV-2 von Willebrand factor vWF [DOI] 10.1038/s41598-022-23168-y PMC 바로가기
Porcine deltacoronavirus E protein induces interleukin-8 production via NF-κB and AP-1 activationArticle Published on 2022-11-012022-11-15 Journal: Veterinary microbiology [Category] SARS, 유전자 메커니즘, 치료제, [키워드] abrogated activated activating Activation acute respiratory syndrome Alpha antiviral immunity AP-1 binding C-terminal domain caused chemokine coronavirus coronavirus disease COVID-19 Cytokine release syndrome deleting demonstrated dependent on domain E E protein expression facilitate help IL-6 IL-8 induce Infection Inflammation inhibitor interleukin-6 IκBα life-threatening Local molecular mechanism motif NF-κB NF-κB pathway nuclear nuclear translocation p65 Pathogenesis PDCoV. Phosphorylation Proinflammatory cytokine promoter protein phosphorylation resulting SARS-CoV-2 Severe case upregulated [DOI] 10.1016/j.vetmic.2022.109553 PMC 바로가기
A modified porous silicon microparticle potentiates protective systemic and mucosal immunity for SARS-CoV-2 subunit vaccineArticle Published on 2022-11-012022-11-15 Journal: Translational research : the journal of laboratory [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] activated airway epithelial cells Antigen B cell Beta Cell cross-reactive delta variant dendritic cell development domain effective elicited facilitated humoral IgA response immune response Immunity induce Inflammation intranasal long-lasting lung mice Microparticle mucosal nasal Parenteral porous prime and boost Protective RBD SARS-CoV-2 SARS-CoV-2 RBD SARS-CoV-2 vaccine subunit type 1 helper vaccination Vaccinations Vaccine variant Viral load [DOI] 10.1016/j.trsl.2022.06.004 PMC 바로가기
The detectability and removal efficiency of SARS-CoV-2 in a large-scale septic tank of a COVID-19 quarantine facility in JapanResearch article Published on 2022-11-012022-10-05 Journal: The Science of the total environment [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activated Activated sludge acute respiratory syndrome association comparable coronavirus coronavirus disease COVID-19 determine E. coli Efficiency Epidemiology Escherichia coli evaluated excluded fecal filtration glycol Japan Mild physical polymerase chain qPCR Quantification method quantified Quantitative quarantine reduction RNA concentration SARS-CoV-2 SARS-CoV-2 particle SARS-CoV-2 RNA Sequencing the SARS-CoV-2 treated Treatment virus was determined Wastewater treatment Wastewater-based epidemiology [DOI] 10.1016/j.scitotenv.2022.157869 [Article Type] Research article
Distinct Immune Phenotypes and Cytokine Profiles in Children with Differing Severity of COVID-19Article Published on 2022-11-012022-11-15 Journal: The Pediatric Infectious Disease Journal [Category] SARS, 진단, 치료기술, [키워드] Absolute lymphocyte count activated acute phase acute respiratory syndrome Anti-inflammatory Antibody Response CD3 CD4 CD8 Cell children children with COVID-19 Clinical outcome clinical presentation coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine profile decrease dependent on disease severity distress effector memory exhibited groups help HLADR IL-1ra IL-1β immune mechanism Immune phenotype Immune profile increase in Infection Inflammatory Laboratory parameters Mild MIS-C no difference not significantly different Patient pediatric profile prospective cohort study RANTES SARS-CoV-2 IgG SARS-CoV2 sera severe disease severity syndrome T cell T cells tumor necrosis factor-α was performed with COVID-19 [DOI] 10.1097/INF.0000000000003669 PMC 바로가기
DNA damage in peripheral blood lymphocytes of severely ill COVID-19 patients in relation to inflammatory markers and parameters of hemostasisArticle Published on 2022-10-262022-11-15 Journal: Mutagenesis [Category] 바이오마커, 치료제, [키워드] activated Analysis Antibiotics Anticoagulant antiviral therapy applied Bearing biochemical C-reactive protein (CRP Chest chest X-ray Concentration contribute control subjects Corticosteroid COVID-19 COVID-19 patient COVID-19 patients demonstrated DNA DNA damage female Female patients Genetic Genome genotoxic healthy control healthy controls hematological parameters Hemostasis hemostasis abnormalities hospitalized COVID-19 patient IL-6 indicated Inflammation Inflammation. Inflammatory marker Laboratory laboratory parameter Laboratory parameters leukocyte lymphocyte neutrophil parameter performed peripheral blood lymphocyte Platelet positive positive correlation positively correlated procalcitonin reagent shown significantly significantly higher smoking statistically study population subjects therapy variety viral infections was measured X ray [DOI] 10.1093/mutage/geac011 PMC 바로가기
Interaction of HDAC2 with SARS-CoV-2 NSP5 and IRF3 Is Not Required for NSP5-Mediated Inhibition of Type I Interferon Signaling PathwayArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 치료제, [키워드] abrogate activated addition bind binding biological significance cellular processe complex disrupt DNA Epigenetic Evidence expression favor Gene Expression HDAC2 Host host antiviral response IFN response IFN signaling pathway IFN-stimulated genes IFNβ IL-1β IL-6 immune response gene inhibit inhibition inhibitory interact Interaction interferons involved IRF3 nsp5 over Pathogenesis pathway promote promoter promoters protease Protease activity protein interaction protein-protein interactions reduce Regulation Replication repress required RNA SARS-CoV-2 SARS-CoV-2 protein Signaling signaling pathway significantly subset Type Type I IFN type I IFN signaling. type I interferon viral infection viral infections Viral protein virus [DOI] 10.1128/spectrum.02322-22 PMC 바로가기